Navigating fatigue: Strategies for managing fatigue in liver disease

Chronic fatigue, lasting over 6 months, is a primary concern in patients with chronic liver disease and greatly impacts their daily lives1,2.

Diagnosis of fatigue due to liver diseases3

Fatigue diagnosis in CLD is complicated and requires4

Assessment of fatigue in liver disease4

Management of fatigue in liver disease4

A structured approach TrACE algorithm is employed to manage fatigue in liver disease involving 4 steps:

Treatment of fatigue in liver disease5

The treatment of CLD-related fatigue requires a comprehensive strategy that focuses on the patient as a whole.

Patients with CLD frequently experience fatigue significantly impacting their day-to-day activities and quality of life. Effective management strategies are crucial to alleviate symptoms and improve overall well-being.


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  2. Gerber LH, Weinstein AA, Mehta R, Younossi ZM. Importance of fatigue and its measurement in chronic liver disease. World J Gastroenterol. 2019;25(28):3669-3683. Doi: 10.3748/wjg.v25.i28.3669.
  3. Bhandari K, Kapoor D. Fatigue in Cirrhosis. J Clin Exp Hepatol. Mar-Apr 2022;12(2):617-624. doi:10.1016/j.jceh.2021.08.0284.
  4. Swain MG, Jones DEJ. Fatigue in chronic liver disease: New insights and therapeutic approaches. Liver Int. Jan 2019;39(1):6-19. Doi:10.1111/liv.13919.
  5. Effiong A, Kumari P. Pharmacotherapies for fatigue in chronic liver disease (CLD): a systematic review and meta-analysis (protocol). Syst Rev. 2018;7(1):28. Published 2018 Feb 14. doi:10.1186/s13643-018-0688-7